pI: 6.3349 |
Length (AA): 552 |
MW (Da): 61546 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
50 | 542 | 4g84 (B) | 53 | 501 | 51.00 | 0.000000039 | 1 | 1.29412 | 0.06 |
51 | 540 | 4x5o (B) | 54 | 499 | 62.00 | 0 | 1 | 1.10628 | 0.83 |
53 | 544 | 4g84 (A) | 56 | 503 | 55.00 | 0 | 1 | 1.3968 | -0.32 |
481 | 543 | 1htt (A) | 361 | 423 | 21.00 | 0.00032 | 0.4 | 0.39913 | -0.78 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_126806)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G46100 | Histidyl-tRNA synthetase 1 |
Arabidopsis thaliana | AT3G02760 | histidyl-tRNA synthetase |
Babesia bovis | BBOV_IV001190 | histidyl-tRNA synthetase, putative |
Babesia bovis | BBOV_III005180 | hypothetical protein |
Brugia malayi | Bm1_21685 | histidyl-tRNA synthetase |
Candida albicans | CaO19.11533 | histidyl-tRNA synthetase |
Candida albicans | CaO19.4051 | histidyl-tRNA synthetase |
Caenorhabditis elegans | CELE_T11G6.1 | Protein HARS-1, isoform B |
Cryptosporidium hominis | Chro.80461 | histidyl-tRNA synthetase (EC 6.1.1.21) (Histidine--tRNA ligase) (HisRS) |
Cryptosporidium parvum | cgd8_4010 | histidyl-tRNA synthetase |
Chlamydia trachomatis | CT_543 | histidine--tRNA ligase |
Dictyostelium discoideum | DDB_G0269822 | histidine-tRNA ligase |
Dictyostelium discoideum | DDB_G0274159 | histidine-tRNA ligase |
Drosophila melanogaster | Dmel_CG6335 | Histidyl-tRNA synthetase |
Escherichia coli | b2514 | histidyl tRNA synthetase |
Echinococcus granulosus | EgrG_001008100 | histidyl tRNA synthetase |
Entamoeba histolytica | EHI_180020 | histidyl-tRNA synthetase, putative |
Echinococcus multilocularis | EmuJ_001008100 | histidyl tRNA synthetase |
Giardia lamblia | GL50803_22808 | Histidyl-tRNA synthetase |
Homo sapiens | ENSG00000112855 | histidyl-tRNA synthetase 2, mitochondrial |
Homo sapiens | ENSG00000170445 | histidyl-tRNA synthetase |
Leishmania braziliensis | LbrM.30.0710 | histidyl-tRNA synthetase, putative |
Leishmania donovani | LdBPK_300650.1 | histidyl-tRNA synthetase, putative |
Leishmania infantum | LinJ.30.0650 | histidyl-tRNA synthetase, putative |
Leishmania major | LmjF.30.0630 | histidyl-tRNA synthetase, putative |
Leishmania mexicana | LmxM.29.0630 | histidyl-tRNA synthetase, putative |
Loa Loa (eye worm) | LOAG_05136 | histidyl-tRNA synthetase |
Mycobacterium leprae | ML0494 | Probable histidyl-tRNA synthase HisS (Histidine--tRNA ligase) (HisRS) (Histidine--Translase) |
Mus musculus | ENSMUSG00000019143 | histidyl-tRNA synthetase 2, mitochondrial (putative) |
Mus musculus | ENSMUSG00000001380 | histidyl-tRNA synthetase |
Mycobacterium tuberculosis | Rv2580c | Probable histidyl-tRNA synthetase HisS (histidine--tRNA ligase) (HISRS) (histidine--translase) |
Mycobacterium ulcerans | MUL_1732 | histidyl-tRNA synthetase |
Neospora caninum | NCLIV_019550 | histidyl-tRNA synthetase, putative |
Oryza sativa | 4330767 | Os02g0754700 |
Oryza sativa | 4337830 | Os05g0150900 |
Plasmodium berghei | PBANKA_0834800 | histidine--tRNA ligase, putative |
Plasmodium berghei | PBANKA_1308900 | histidine--tRNA ligase, putative |
Plasmodium falciparum | PF3D7_0934000 | histidine--tRNA ligase, putative |
Plasmodium falciparum | PF3D7_1445100 | histidine--tRNA ligase, putative |
Plasmodium knowlesi | PKNH_0732700 | histidine--tRNA ligase, putative |
Plasmodium knowlesi | PKNH_1237200 | histidine--tRNA ligase, putative |
Plasmodium vivax | PVX_087015 | histidine--tRNA ligase, putative |
Plasmodium vivax | PVX_118235 | histidine--tRNA ligase, putative |
Plasmodium yoelii | PY03706 | histidyl-tRNA synthetase, putative |
Plasmodium yoelii | PY00739 | CCAAT-box DNA binding protein subunit B |
Saccharomyces cerevisiae | YPR033C | histidine--tRNA ligase |
Schistosoma japonicum | Sjp_0201330 | expressed protein |
Schistosoma japonicum | Sjp_0007710 | ko:K01892 histidyl-tRNA synthetase [EC6.1.1.21S], putative |
Schistosoma mansoni | Smp_023360.1 | histidyl-tRNA synthetase |
Schistosoma mansoni | Smp_023360.2 | histidyl-tRNA synthetase |
Schmidtea mediterranea | mk4.000648.09 | Probable histidineALQ-tRNA ligase, mitochondrial |
Schmidtea mediterranea | mk4.006253.02 | Probable histidineALQ-tRNA ligase, mitochondrial |
Schmidtea mediterranea | mk4.033250.01 | Probable histidineALQ-tRNA ligase, mitochondrial |
Trypanosoma brucei gambiense | Tbg972.6.1800 | histidyl-tRNA synthetase, putative |
Trypanosoma brucei | Tb927.6.2060 | histidyl-tRNA synthetase |
Trypanosoma congolense | TcIL3000_0_25100 | histidyl-tRNA synthetase |
Trypanosoma congolense | TcIL3000_6_1720 | histidyl-tRNA synthetase |
Trypanosoma cruzi | TcCLB.507019.40 | histidyl-tRNA synthetase |
Toxoplasma gondii | TGME49_280600 | histidyl-tRNA synthetase (HisRS), putative |
Treponema pallidum | TP0641 | histidyl-tRNA synthetase |
Theileria parva | TP01_0145 | histidyl-tRNA synthetase, putative |
Theileria parva | TP02_0435 | histidyl-tRNA synthetase, putative |
Trichomonas vaginalis | TVAG_342610 | interferon-induced, double-stranded RNA-activated protein kinase, putative |
Wolbachia endosymbiont of Brugia malayi | Wbm0412 | histidyl-tRNA synthetase |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.6.2060 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.6.2060 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.6.2060 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.6.2060 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
b2514 | Escherichia coli | essential | goodall |
CELE_T11G6.1 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_T11G6.1 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_T11G6.1 | Caenorhabditis elegans | slow growth | wormbase |
CELE_T11G6.1 | Caenorhabditis elegans | sterile | wormbase |
YPR033C | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_1308900 | Plasmodium berghei | Essential | plasmo |
TGME49_280600 | Toxoplasma gondii | Probably essential | sidik |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | histidyl-tRNA synthetase | Compounds | References |